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1

Colon Cancer-Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins

Travica, S., Pors, K., Loadman, P. M., Shnyder, S. D., Johansson, I., Alandas, M. N., Sheldrake, H. M., Mkrtchian, S., Patterson, L. H., Ingelman-Sundberg, M.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

2

The hollow fibre model - facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare

Suggitt, Marie, Cooper, Patricia, Shnyder, Steven, Bibby, Michael

Journal:

International Journal of Oncology

Year:

2006

Language:

english

File:

PDF, 182 KB

english, 2006

3

Synthesis of cryptolepine analogues as potential bioreducible anticancer agents

Scott Seville, Roger M. Phillips, Steven D. Shnyder, Colin W. Wright

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 410 KB

english, 2007

4

Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.

Michael Stavri, K.T. Mathew, Andrew Gordon, Steven D. Shnyder, Robert A. Falconer, Simon Gibbons

Journal:

Year:

2008

Language:

english

File:

PDF, 184 KB

english, 2008

5

Improved preparation and detection of cytochrome P450 isoforms using MS methods

Chris W. Sutton, Mark Sutherland, Steve Shnyder, Laurence H. Patterson

Journal:

Year:

2010

Language:

english

File:

PDF, 115 KB

english, 2010

6

Dynamics of tumor growth in Brattleboro and WAG rats injected with Walker 256 carcinosarcoma cells in different doses

I. I. Khegay, N. A. Popova, L. S. Ganilova, E. P. Shnyder, L. N. Ivanova

Journal:

Bulletin of Experimental Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

7

P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma

Shnyder, SD, Hayes, AJ, Pringle, J, Archer, CW

Journal:

British Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 1.10 MB

english, 1998

8

Retargeted adenoviral cancer gene therapy for tumour cells overexpressing epidermal growth factor receptor or urokinase-type plasminogen activator receptor

Harvey, T J, Burdon, D, Steele, L, Ingram, N, Hall, G D, Selby, P J, Vile, R G, Cooper, P A, Shnyder, S D, Chester, J D

Journal:

Year:

2010

Language:

english

File:

PDF, 688 KB

english, 2010

9

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo

Lamont, F R, Tomlinson, D C, Cooper, P A, Shnyder, S D, Chester, J D, Knowles, M A

Journal:

British Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 673 KB

english, 2010

10

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent

Gary P. Wilkinson, James P. Taylor, Steve Shnyder, Patricia Cooper, Phil W. Howard, David E. Thurston, Terence C. Jenkins, Paul M. Loadman

Journal:

Investigational New Drugs

Year:

2004

Language:

english

File:

PDF, 165 KB

english, 2004

11

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Pors, Klaus, Loadman, Paul M., Shnyder, Steven D., Sutherland, Mark, Sheldrake, Helen M., Guino, Meritxell, Kiakos, Konstantinos, Hartley, John A., Searcey, Mark, Patterson, Laurence H.

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 1.67 MB

english, 2011

12

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

Roger M. Phillips, Mohammed Jaffar, Derek J. Maitland, Paul M. Loadman, Steven D. Shnyder, Gillian Steans, Patricia A. Cooper, Amanda Race, Adam V. Patterson, Ian J. Stratford

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 176 KB

english, 2004

13

An agarose spot chemotaxis assay for chemokine receptor antagonists

Victoria Vinader, Yousef Al-Saraireh, Helen L. Wiggins, Joshua Z. Rappoport, Steve D. Shnyder, Laurence H. Patterson, Kamyar Afarinkia

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 766 KB

english, 2011

14

Use of the hollow fiber assay for the evaluation of DNA damaging agents

J. Pedro Veiga, Patricia A. Cooper, Klaus Pors, Laurence H. Patterson, Michael C. Bibby, Steven D. Shnyder

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 1.13 MB

english, 2011

15

In vitro and in vivo activity of LS 4477 and LS 4559, novel analogues of the tubulin binder estramustine

K.M Nicholson, R.M Phillips, S.D Shnyder, M.C Bibby

Journal:

European Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 319 KB

english, 2002

16

Synthesis and Biological Evaluation of Colchicine B-Ring Analogues Tethered with Halogenated Benzyl Moieties

Cosentino, Laura, Redondo-Horcajo, Mariano, Zhao, Ying, Santos, Ana Rita, Chowdury, Kaniz F., Vinader, Victoria, Abdallah, Qasem M. A., Abdel-Rahman, Hamdy, Fournier-Dit-Chabert, Jérémie, Shnyder, Ste

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

17

607 Tumour specific delivery of cytostatics encapsulated in novel phospholipase A2 degradable liposomes

S.S. Jensen, L.T. Jensen, J. Davidsen, J.H. Gill, S.D. Shnyder, M.C. Bibby, P.T.L. Høyrup, K. Jørgensen

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

18

604 Secretory phospholipase A2 as tumour specific trigger for targeted delivery of a novel class of liposomal prodrug anticancer etherlipids

S.S. Jensen, L.T. Jensen, J. Davidsen, J.H. Gill, S.D. Shnyder, M.C. Bibby, P.T.L. Høyrup, K. Jørgensen

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 134 KB

english, 2004

19

312 POSTER Preclinical evaluation of a rationally designed novel class of non-hydroxamate Histone Deacetylase inhibitors (HDACi)

J.H. Gill, C.W.G. Fishwick, V. Androutsopoulos, A. Mohanarajah, T. Khamnaen, L.H. Patterson, S.D. Shnyder, P.M. Loadman, R. Grigg

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 60 KB

english, 2006

20

24 INVITED The evolution of CYPs from metabolising enzymes to potential targets in cancer therapy development

L.H. Patterson, K. Pors, P.M. Loadman, M. Sutherland, J. Gill, H. Sheldrake, S.D. Shnyder

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

21

331 POSTER CYP1A1 activation and pharmacokinetics of a novel chloromethylpyrrollolindoline with potential as a tumour selective prodrug

A.D. Race, K. Pors, S.D. Shnyder, T.C. Cooper, H.M. Sheldrake, M. Searcey, L.H. Patterson, P.M. Loadman

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 84 KB

english, 2008

22

263 A non-invasive bioluminescent imaging technique for monitoring shutdown of the tumour vasculature

A.C. O'Farrell, P.A. Cooper, R.A. Falconer, M.C. Bibby, J.H. Gill, S.D. Shnyder

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

23

Synthesis of Some Cryptolepine Analogues, Assessment of Their Antimalarial and Cytotoxic Activities, and Consideration of Their Antimalarial Mode of Action

Onyeibor, Onyeka, Croft, Simon L., Dodson, Hilary I., Feiz-Haddad, Mohammad, Kendrick, Howard, Millington, Nicola J., Parapini, Silvia, Phillips, Roger M., Seville, Scott, Shnyder, Steven D., Taramell

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 142 KB

english, 2005

24

Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity

Sheldrake, Helen M., Travica, Sandra, Johansson, Inger, Loadman, Paul M., Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J., Reuillon, Tristan, Shnyder, Steven D., Mkrtchia

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 695 KB

english, 2013

25

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

Shnyder, Steve D., Fu, Ying, Habtemariam, Abraha, van Rijt, Sabine H., Cooper, Patricia A., Loadman, Paul M., Sadler, Peter J.

Journal:

Year:

2011

Language:

english

File:

PDF, 131 KB

english, 2011

26

RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis

Sutherland, Mark, Gordon, Andrew, Shnyder, Steven, Patterson, Laurence, Sheldrake, Helen

Journal:

Year:

2012

Language:

english

File:

PDF, 714 KB

english, 2012

27

P76. A histochemical assessment of cell death in human osteosarcoma

Shnyder, SD, Pringle, J, Bowen, ID, Archer, CW

Journal:

Year:

1994

Language:

english

File:

PDF, 147 KB

english, 1994

28

204 Modulation of Tumour Cell Migration by Inhibition of Polysialic Acid Biosynthesis

Springett, B.R., Al-Saraireh, Y.M.J., Sutherland, M., Patterson, L.H., Shnyder, S.D., Falconer, R.A.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 81 KB

english, 2012

29

163 Functional Screens to Identify Mechanisms of Resistance to FGFR Inhibitors in FGFR Amplified and Mutated Cell Lines

Abreu, M. Herrera, Garcia-Murilla, I., Pearson, A., Shnyder, S., Knowles, M., Turner, N.C.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 59 KB

english, 2012

30

L’index d’obstruction arteriel au scanner predit-il le risque de mortalite a court terme dans l’embolie pulmonaire aiguë ?

Kamel, E., Rizzo, E., Al Qahtany, S., Shnyder, P., Qanadli, S.D.

Journal:

Journal de Radiologie

Year:

2009

Language:

french

File:

PDF, 205 KB

french, 2009

31

520: Investigation of the expression and the role of avβ3, avβ5 and a5β1 integrins in head and neck cancers

Ahmedah, H., Patterson, L., Shnyder, S., Sheldrake, H.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 69 KB

english, 2014

32

Organometallic Osmium Arene Complexes with Potent Cancer Cell Cytotoxicity

Fu, Ying, Habtemariam, Abraha, Pizarro, Ana M., van Rijt, Sabine H., Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J., Sadler, Peter J.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.92 MB

english, 2010

33

Triplex Profiling of Functionally Distinct Chaperones (ERp29/PDI/BiP) Reveals Marked Heterogeneity of the Endoplasmic Reticulum Proteome in Cancer

Shnyder, Steven D., Mangum, Jonathan E., Hubbard, Michael J.

Journal:

Journal of Proteome Research

Year:

2008

Language:

english

File:

PDF, 4.91 MB

english, 2008

34

Synthesis of DNA-Directed Pyrrolidinyl and Piperidinyl Confined Alkylating Chloroalkylaminoanthraquinones: Potential for Development of Tumor-Selective N -Oxides

Pors, Klaus, Shnyder, Steven D., Teesdale-Spittle, Paul H., Hartley, John A., Zloh, Mire, Searcey, Mark, Patterson, Laurence H.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 503 KB

english, 2006

35

Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity against Solid Tumors and Reduced Potential for Cardiovascular Toxicity

Gill, Jason H., Loadman, Paul M., Shnyder, Steven D., Cooper, Patricia, Atkinson, Jennifer M., Ribeiro Morais, Goreti, Patterson, Laurence H., Falconer, Robert A.

Journal:

Molecular Pharmaceutics

Year:

2014

Language:

english

File:

PDF, 2.08 MB

english, 2014

36

Sodium Pancratistatin 3,4- O -Cyclic Phosphate, a Water-Soluble Synthetic Derivative of Pancratistatin, Is Highly Effective in a Human Colon Tumor Model †

Shnyder, Steven D., Cooper, Patricia A., Millington, Nicola J., Gill, Jason H., Bibby, Michael C.

Journal:

Journal of Natural Products

Year:

2008

Language:

english

File:

PDF, 969 KB

english, 2008

37

Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells

van Rijt, Sabine H., Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D., Sadler, Peter J.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.05 MB

english, 2014

38

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

Vinader, Victoria, Sadiq, Maria, Sutherland, Mark, Huang, Mengying, Loadman, Paul M., Elsalem, Lina, Shnyder, Steven D., Cui, Hongjuan, Afarinkia, Kamyar, Searcey, Mark, Patterson, Laurence H., Pors,

Journal:

Year:

2015

Language:

english

File:

PDF, 689 KB

english, 2015

39

Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity

Krippner-Heidenreich, A., Grunwald, I., Zimmermann, G., Kuhnle, M., Gerspach, J., Sterns, T., Shnyder, S. D., Gill, J. H., Mannel, D. N., Pfizenmaier, K., Scheurich, P.

Journal:

The Journal of Immunology

Year:

2008

Language:

english

File:

PDF, 752 KB

english, 2008

40

289 Progress in drugging CYP1A1, 1B1 and CYP2W1 overexpressed in cancer

Pors, K., Le Morvan, V., Travica, S., Shnyder, S.D., Sutherland, M., Sheldrake, H.M., Searcey, M., Johansson, I., Mkrtchian, S., Loadman, P.M., Robert, J., Ingelman-Sundberg, M., Patterson, L.H.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 61 KB

english, 2014

41

Non-invasive molecular imaging for preclinical cancer therapeutic development

O'Farrell, AC, Shnyder, SD, Marston, G, Coletta, PL, Gill, JH

Journal:

British Journal of Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.34 MB

english, 2013

42

NCAM polysialylation during adherence transitions: Live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7

Smith, Paul J., Furon, Emeline, Wiltshire, Marie, Chappell, Sally, Patterson, Laurence H., Shnyder, Steven D., Falconer, Robert A., Errington, Rachel J.

Journal:

Cytometry Part A

Year:

2013

Language:

english

File:

PDF, 10.01 MB

english, 2013

43

Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo

Harvey, T J, Hennig, I M, Shnyder, S D, Cooper, P A, Ingram, N, Hall, G D, Selby, P J, Chester, J D

Journal:

Cancer Gene Therapy

Year:

2011

Language:

english

File:

PDF, 772 KB

english, 2011

44

ERp29 Is a Ubiquitous Resident of the Endoplasmic Reticulum with a Distinct Role in Secretory Protein Production

Shnyder, S. D., Hubbard, M. J.

Journal:

Journal of Histochemistry & Cytochemistry

Year:

2002

Language:

english

File:

PDF, 374 KB

english, 2002

45

Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate

Kirwan, I. G., Loadman, P. M., Swaine, D. J., Anthoney, D. A., Pettit, G. R., Lippert, J. W., Shnyder, S. D., Cooper, P. A., Bibby, M. C.

Journal:

Clinical Cancer Research

Year:

2004

Language:

english

File:

PDF, 133 KB

english, 2004

46

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts

Williams, K. J., Albertella, M. R., Fitzpatrick, B., Loadman, P. M., Shnyder, S. D., Chinje, E. C., Telfer, B. A., Dunk, C. R., Harris, P. A., Stratford, I. J.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 779 KB

english, 2009

47

Fibroblast Growth Factor Receptor 1 Promotes Proliferation and Survival via Activation of the Mitogen-Activated Protein Kinase Pathway in Bladder Cancer

Tomlinson, D. C., Lamont, F. R., Shnyder, S. D., Knowles, M. A.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 373 KB

english, 2009

48

The Microtubule Depolymerizing Agent CYT997 Causes Extensive Ablation of Tumor Vasculature In Vivo

Burns, C. J., Fantino, E., Powell, A. K., Shnyder, S. D., Cooper, P. A., Nelson, S., Christophi, C., Malcontenti-Wilson, C., Dubljevic, V., Harte, M. F., Joffe, M., Phillips, I. D., Segal, D., Wilks,

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

49

Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder

Sutherland, M., Gill, J. H., Loadman, P. M., Laye, J. P., Sheldrake, H. M., Illingworth, N. A., Alandas, M. N., Cooper, P. A., Searcey, M., Pors, K., Shnyder, S. D., Patterson, L. H.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013

50

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases

Atkinson, J. M., Falconer, R. A., Edwards, D. R., Pennington, C. J., Siller, C. S., Shnyder, S. D., Bibby, M. C., Patterson, L. H., Loadman, P. M., Gill, J. H.

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 486 KB

english, 2010

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